Formulation and Evaluation of NabumetoneEmulgel for Topical Drug Delivery
Rashmi B Surekar, Twarita D Deshpande, Onkar V Jadhav, Anuj J Shinde
Abstract:
Nabumetone is commonly used to relieve pain and inflammation, especially in conditions like arthritis. However, its use through oral administration poses certain difficulties. These include its poor solubility in water, which limits its absorption, and a tendency to irritate the gastrointestinal tract, which may lead to discomfort or other side effects in patients. To overcome these limitations, the present investigation focused on developing a topical emulgel formulation. Carbopol 934 and Hydroxypropyl Methylcellulose K15M (HPMC K15M) were employed as gelling agents, and their concentrations were systematically varied to assess their influence on the drug release profile. Emulsion systems were systematically developed using light liquid paraffin as the oil component, Tween 80 as the primary surfactant, and an appropriate co-surfactant. To identify the optimal emulsification zone, pseudoternary phase diagrams were constructed and analyzed. The final emulgel was prepared by incorporating the optimized emulsion into gel bases containing different concentrations of the gelling agents (1.5%, 2.0%, and 2.5%). Comprehensive evaluation of the formulations indicated that the optimized batch, F2, exhibited favorable physicochemical stability in terms of pH, viscosity, and cumulative drug release percentage under ambient and accelerated storage conditions.
Keywords: Nabumetone, Emulgel, Topical Delivery, Rheumatoid Arthritis, Emulsion.
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