Abstract:
A simple light-responsive azobenzene-N-Succinylchitosan (AZO-NSC) polymer has been investigated for its ability to act as a drug carrier. The AZO-NSC hydrogel bead was prepared by the ionic gelation method for the controlled delivery of kojic dipalmitate. The structure and surface morphology of the hydrogel were characterized by FTIR and SEM, respectively. The hydrogel showed good light-responsive. The release of the encapsulated drug from the hydrogel was regulated by (trans–cis) photoisomerization of azobenzene moiety. The in vitro release behavior of drug from these hydrogel systems is revelative of the potential of the hydrogel for controlled drug delivery.

Keywords: Kojic Dipalmitate, Light-Responsibility, Hydrogel, N-Succinylchitosan Azobenzene.