References:
[1] Verma P, Thakur AS, Deshmukh K, Jha AK, Verma S. Routes of drug administration. International Journal of Pharmaceutical Studies and Research. 2010 Jul;1(1):54-9.

[2] Vinchurkar K, Sainy J, Khan MA, Sheetal MA, Mishra DK, Dixit P. Features and facts of a gastroretentive drug delivery system-a review. Turkish journal of pharmaceutical sciences. 2022 Aug;19(4):476.

[3] Schneider F, Koziolek M, Weitschies W. Invitro and in vivo test methods for the evaluation of gastroretentive dosage forms. Pharmaceutics. 2019 Aug 16;11(8):416.

[4] Arunachalam A, Karthikeyan M, Konam K, Prasad HP, Sethuraman S, Ashutoshkumar S, Manidipa S. Floating drug delivery systems: A review. Int. J. Res. Pharm. Sci. 2011 Jan 20;2(1):76-83.

[5] Peppas N, Langer R. New challenges in biomaterials. Science1994; 263:171520.

[6] HB N, Bakliwal S, Pawar S. In-situ gel: new trends in controlled and sustained drug delivery system. International Journal of PharmTech Research. 2010 Apr;2(2):1398-408.

[7] Patange BS and Deshmukh VN. Floating oral In-situ gel: A Review. J Emg Tech and Innvo Res. 2023 Dec 16;9(2):247-287.

[8] Hansan M, Mathew SE, Irene AM. Advances in gastroretentive drug delivery systems: Formulation strategy and therapeutic applications. International Journal of Science and Research Archive. 2024;11(1):1078-88.

[9] Nale AA, Thorat PA, Mulla JASG. Development and Evaluation of Levofloxacin-Based In situ Floating Gel for Enhanced Gastric Retention. Indian Journal of Pharmaceutical Education and Research. 2026;60(1s):s124-s135.

[10] Patil VS, Mulla JA, Kapse MV. Formulation and evaluation of floating tablets of amla and ginger extract for prolonged gastric retention. Journal of Ethnopharmacology and Toxicology. 2024 Dec 31;2(2):1-1.

[11] Tipugade OB, Mulla JA. Indian Journal of Novel Drug Delivery. Indian Journal of Novel Drug Delivery. 2022 Oct;14(4):181-91.

[12] Potekar PM, Mulla JA, Doijad RC. Gastro-Retentive Drug Delivery Systems: A Review. Indian Journal of Novel Drug Delivery. 2017;9(3):159-66.

[13] Mandal S, Ratan GN, Mulla JS, Thimmasetty J, Kaneriya A. Design and in vitro evaluation of gastro retentive sustained release tablets of tizanidine hydrochloride. Indian Journal of Novel Drug delivery. 2010;2(4):144-52.

[14] Foda NH, Ali SM. Gastroretentive drug delivery systems as a potential tool for enhancing the efficacy of antibiotics: a review. International journal of pharma and bio sciences. 2011;2(2):94-104.

[15] Talukder R and Fissihi R. Gastroretentive Delivery Systems: A Mini review Drug Dev. Ind. Pharm, 2004; 30:1019-1028.

[16] Garg RG, Gupta GD. Progress in controlled gastroretentive delivery systems. Tropical journal of pharmaceutical research. 2008 Sep 11;7(3):1055-66.

[17] Bhatt P, Khatri N, Kumar M, Baradia D, Misra A. Microbeads mediated oral plasmid DNA delivery using polymethacrylate vectors: an effectual groundwork for colorectal cancer. Drug delivery. 2015;22(6):849-61.

[18] Bromberg LE, Ron ES. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. Adv Drug Deliv Rev, 1998; 31:197-221.

[19] Choi BY, Park HJ, Hwang SJ, Park JB. Preparation of alginate beads for floating drug delivery system: Effects of CO2 gas-forming agents. Int J Pharm. 2002;239:81-91.

[20] S.R.Lahoti., R.K.Shinde., S.A.Ali., B.Gulecha., PH triggered sol-gel transition system of ofloxacin for prolonged gastric retention. Der Pharmacia Sinica, 2 (5): 235-250, (2011).

[21] B. Padmasri, R. Nagarju, D. Prasanth. a comprehensive review on in situ gels: Int J App Pharm, Vol 12,2020:pp.24-25.

[22] Arora S. Floating drug delivery systems: A review. AAPS PharmSciTech. 2005;6(3) 47, E372-390.

[23] C.N.Patel., N.P.Jivani., The influence of variation of gastric pH on the gelation and release characteristics of in situ gelling sodium alginate formulations. Acta Pharmaceutical Sciences, 52: 365-369, (2010

[24] R. Pahwa, S. Bhagwan, V. Kumar, K. Kohli, .Role of Natural Polymers in the Development of Floating Drug Delivery Systems. Journal of Pharmacy Research 2010, 3(6): pp. 1312-1318.

[25] HB N, Bakliwal S, Pawar S. In-situ gel: new trends in controlled and sustained drug delivery system. International Journal of PharmTech Research. 2010 Apr;2(2):1398-408.

[26] Ganguly S, Dash AK. A novel in situ gel for sustained drug delivery and targeting. International journal of pharmaceutics. 2004 May 19;276(1-2):83-92.

[27] Akshada V Kumbhar, Priyanka A Thorat, Jameel Ahmed S. Mulla. Development and assessment of risperidone-loaded niosomalin situ gel for nasal drug delivery. Indian Drugs. 2025;62(12):41-50.

[28] Patole PJ, Mulla JA. Liposomal In Situ Gel: A Novel Approach for the Treatment of Parkinson’s Disease via Intranasal Drug Delivery. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025 Mar 10;17(1):53-62.

[29] Hiremath SS, Dasankoppa FS, Nadaf A, Jamakandi VG, Mulla JS, Sholapur HN. Formulation and evaluation of a novel in situ gum based ophthalmic drug delivery system of linezolid. ScientiaPharmaceutica. 2008 Sep;76(3):515-32.

[30] Bhalerao KK, Kamble MS, Aute PP, Dange SM, Chavan RP, Vadiya KK, Munot SB, Chaudhari PD. A short Review on Stomach Specific Floating in-situ gel. Journal of biomedical and pharmaceutical research. 2012;1(3):01-4.

[31] Kant A, Reddy S, Shankraiah MM, Venkatesh JS, Nagesh C. In situ gelling system-an overview. Pharmacologyonline. 2011;2(1):28-44.

[32] Neha V, Manoj BA. Gastro Retentive in situ Gel Formulation–an overview. International Bulletin and Drug Research. 2013;3(5):69-82.

[33] Jadhav SL, Benerjee SK. Formulation and evaluation of floating in situ gel of nizatidine. International Journal of Research in Pharmaceutical Sciences. 2013;4(2):250-5.

[34] Shah J. In situ gel: A novel approach of gastroretentive drug delivery. Asian journal of biomedical and pharmaceutical sciences. 2012 Jan 1;2(8).

[35] Qiu Y, Park K. Environment-sensitive hydrogels for drug delivery. Advanced drug delivery reviews. 2001 Dec 31;53(3):321-39.

[36] Musmade N, Jadhav A, Moin P, Patil S, Gupta A. An overview of in situ gel forming implants: current approach towards alternative drug delivery system. J BiolChem Chron. 2019;5:14-21.

[37] Sudhi U S, Kumar S, Nowfiya F N, Mathan S, Dharan S, Floating Oral In-Situ Gelling System: A Review. J. Pharm. Sci. & Res. Vol. 12(10), 2020, pp. 1315-1319.

[38] Gupta A, Sharma N, Khinchi MP, Agrawal D. A Review On Current Approaches In Floating Drug Delivery System. Asian Journal of Pharmaceutical Research and Development. 2013 Jul 1:24-37.

[39] Reddy BV, Navaneetha K, Deepthi PS. Gastroretentive drug delivery system-A review. Journal of Global Trends in Pharmaceutical Sciences. 2013 Jan;4(1):1018-33.

[40] C.Kapadia, V.Mane, Raft-forming agents: Antireflux formulations, Drug Dev. Ind. Pharm., 33(12), 2007, pp. 1350-1361.

[41] Al-Shamklani A, Bhakoo M, Tuboku MA, Duncan R. Evaluation of the biological properties of alginates and gellan and xanthan gum. ProcIntSymp Control Release Bioact Mater 1991;18:213-4.
[42] K. Bhardwaj, Kanwar M, Lal R, Gupta A. Natural gums and modified natural gums as sustained release carriers. Drug Dev. Ind. Pharm., 26(10). pp. 1025-1038.

[43] Gellan gum, http://en.wikipedia.org/wiki/Gellan_gum accessed on 20 Jan. 2010.

[44] PS Rajinikanth, B.Mishra, Preparation and in vitro characterization of gellan based floating beads of acetohydroxamic acid for eradication of Helicobacter pylori, Acta Pharm.57(4), 2007, pp.413-427.

[45] L. Bharadwaj, P. Sharma, and RishabhaM, A Short Review on Gastro Retentive Formulations for Stomach Specific Drug Delivery: Special Emphasis on Floating In situ Gel Systems, African J. Basic & Appl. Sci., 3 (6): pp. 305-306.

[46] H Rathod., V. Patel and M. Modasia, In situ gel as a novel approach of gastroretentive drug delivery,International Journal of Pharmacy and Life Sciences, 1(8): pp. 440-447.

[47] Vendruscolo CW, Andreazza IF, Ganter JLMS, Ferrero C, Bresolin TMB, Xanthan and galactomannan (from M. scabrella) matrix tablets for oral controlled delivery of theophylline, Int. J. Pharm., 296(1-2), 2005, 1-11.

[48] RG Shaikh, S. Shah, K. Patel, B. Patel, B. Patel, A Review on Polymers Used in In-Situ Gel Drug Delivery Systems, IJPRS V-1, I-2, 2012, pp.18-27.

[49] Suisha F, Kawasaki N, Miyazaki S, Shirakawa M, Yamatoya K, Sasaki M, Attwood D, Xyloglucan gels as sustained release vehicles for the intraperitoneal administration of mitomycin C, International Journal of Pharmacy, 1998, 172(1-2), pp. 27–32.

[50] Muller RH, Jacobs C, Kayser O, Nanosuspensions as particulate drug formulations in therapy rational for drug development and what we can expect for the future, Advanced Drug Delivery Review, 2001, 47(1), pp. 3–19.

[51] Lin HH, Cheng YL, In-situ thermoreversible gelation of block and star copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) of varying architectures, Macromolecules, 2001, pp.3710–3715.

[52] Sarada K, Firoz S, Padmini K. In-situ gelling system: A review. Int J CurrPharma Rev Res. 2014;15(5):76-90.

[53] Yadav KS, Rajpurohit R, Sharma S. Glaucoma: Current treatment and impact of advanced drug delivery systems. Life sciences. 2019 Mar 15;221:362-76.

[54] Swamy NG, Abbas Z. Mucoadhesivein situ gels as nasal drug delivery systems: an overview. Asian Journal of Pharmaceutical Sciences. 2012 Jun 1;7(3).

[55] Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee SK. Drug delivery systems: An updated review. International journal of pharmaceutical investigation. 2012 Jan;2(1):2.

[56] Almeida H, Amaral MH, Lobão P, Lobo JM. In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations. Drug discovery today. 2014 Apr 1;19(4):400-12.
[57] Hua S. Physiological and pharmaceutical considerations for rectal drug formulations. Frontiers in pharmacology. 2019 Oct 16;10:489933

[58] Bisht R, Nirmal S, Agrawal R, Jain GK, Nirmal J. Injectable in-situ gel depot system for targeted delivery of biologics to the retina. Journal of Drug Targeting. 2021 Jan 2;29(1):46-59.

[59] J. Patel, P. Dandagi, S.Halyalkar, and B. Desai, Formulation and Evaluation of oral floating in situ gel of cefiximetrihydrate by using ß-cyclodextrincomplexation technique for solubility enhancement, WJPPS, Vol 9, Issue 10, 2020, pp. 2616.

[60] K.Itoh., T. Hatakeyama., T.Shimoyama., S.Miyazaki., A.D’Emanuele., D.Attwood., In situ gelling formulation based on methylcellulose/pectin system for oral-sustained drug delivery to dysphagic patients. Drug Development and Industrial Pharmacy, 37(7): 790–797, (2011).

[61] B.D.Jayswal., V.T. Yadav., K.N.Patel.,B.A.Patel.,P.A.Patel., Formulation and Evaluation of Floating In Situ Gel Based Gastro Retentive Drug Delivery of Cimetidine. International Journal for Pharmaceutical Research Scholars (IJPRS),1(2):327-337, (2012).

[62] Linda N, Issa H, Mazen El-Hammadia and Habib A. Floating in-situ-gelling gellan formulations of metformin hydrochloride, J. Chem. Pharm. Res., 2014, 6(7), 1512-1515.

[63] Bazigha K. A. Rasool, 1 A. Khalifa, Eman Abu-Gharbieh , and R. Khan, Employment of Alginate Floating In Situ Gel for Controlled Delivery of Celecoxib: Solubilization and Formulation Studies, BioMed Research International, BioMed. Res. Int., Volume 2020, pp. 3-4.

[64] Patel D., Patel D, and Patel C., Formulation and Evaluation of Floating Oral In Situ Gelling System of Amoxicillin, ISRN Pharmaceutics,Vol .2011, pp. 3-7.

[65] Bazigha K. A. Rasool, 1 A. Khalifa, Eman Abu-Gharbieh , and R. Khan, Employment of Alginate Floating In Situ Gel for Controlled Delivery of Celecoxib: Solubilization and Formulation Studies, BioMed Research International, BioMed. Res. Int., Volume 2020, pp. 3-4.

[66] S. Shinde, P. Sable, B. Lodhi, S. Khan. Review Article A novel approach of gastroretentive drug delivery :in situ gel. Journal of Innovations in Pharmaceuticals and Biological Sciences, 2014; 1(1): pp. 39-59.