Advances in Nanosponge Technology: A Comprehensive Review
Rutuja A Patil, Priyanka A Thorat, Priyanka S Jadhav
Abstract:
Nanosponge technology has emerged as a promising platform for diverse applications, particularly in drug delivery. These unique, cross-linked polymeric micro- or nanoparticles with internal cavities offer significant advantages over conventional delivery systems. This review comprehensively examines the advancements in nanosponge technology, encompassing materials, synthesis methods, characterization techniques, and a wide array of applications. The review begins by defining nanosponges and outlining their key characteristics, highlighting their high porosity, biocompatibility, and capacity for encapsulating various therapeutic agents. It then delves into the diverse polymers employed in nanosponge fabrication, such as hyper-crosslinked polymers, cyclodextrins, and chitosan, and discusses the various synthesis techniques, including emulsion solvent diffusion, Ultrasound-Assisted Synthesis, Hyper crosslinked method, solvent method. A detailed analysis of characterization techniques, such as scanning electron microscopy and transmission electron microscopy and is presented, focusing on assessing size, morphology, porosity, and drug loading/release profiles. The review further explores the broad spectrum of nanosponge applications, with a primary focus on drug delivery, including pharmaceutical applications.
Keywords: Nanosponge Technology, Drug Delivery, Encapsulation, Biocompatibility, Cross-linked Polymers, Characterization Techniques.
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