Abstract: 
Liposomes have been widely investigated since 1970 as drug carriers for improving the delivery of therapeutic agents to specific sites in the body. There are numerous improvements for the treatment of certain diseases by using this technology. Liposomes can be defined as simple microscopic vesicles in which lipid bilayer structures are present with an aqueous volume entirely enclosed by a membrane, composed of lipid molecule. Liposomes are biodegradable and essentially non‐toxic vehicles. They can encapsulate both hydrophilic and hydrophobic materials, and are utilized as drug carriers in drug delivery. Liposomes are generally classified based upon structure, method of preparation, composition and application. The prepared liposomes are characterized for visual appearance, liposomal size distribution, lamillarity, liposome stability, entrapped volume and surface charges. The liposomes have many applications which increase its importance over other formulations. The current pharmaceutical preparations of liposome-based therapeutic systems mainly result from our understanding of lipid-drug interactions and liposome disposition mechanisms. This review mainly focuses on the advantages and limitations of liposomes, different methods for the preparation and applications of liposomes. In this review discussion was made about the stability problems of liposomes.

Keywords: Multi Lamellar Large Vesicles, Stable Plurilamellar Vesicles, Dehydration‐ rehydration Vesicles, Reverse Phase Evaporation Technique.