Volume 12

October-December 2020​

Bioavailability enhancement and ‎dissolution rate of poor water ‎soluble drug by solid dispersion ‎technique

Ajay Kumar Shukla, Ram Singh Bishnoi, Manish Kumar, C P Jain, Ritesh Tiwari, Ritu Jain

Abstract:
The aim of the present study was to increase solubility, dissolution rate and improvement of oral bioavailability of water insoluble nifedipine (NFD) drug with development of their solid dispersion by using solvent evaporation method. Solid dispersion of nifdipine was prepared by solvent evaporation method using polyethylene glycol 6000 (PEG- 6000), PVP K40000 in different drug: polymer ratios (1:2, 1:3, 1:4, 1:5) and tween-80 as surfactant was used. The solid dispersion of NFD was evaluated, using FTIR, X‐ray diffraction, DSC and in-vitro dissolution method. The X-ray diffraction pattern represented the amorphous form; FTIR indicated no any interaction was found between drug-polymer and DSC respectively.  The solid dispersion with PVP K40000 at 1:4 ratio, and was exhibited significant higher drug release profile when compared to pure drug and marketed product. The % cumulative drug release of solid dispersion and marketed product of nifedipine was found 98.46±.20% and 76.23.46±.74%. The solid dispersion of nifedipine was found stable, under stability study in accelerated storage conditions. Solid dispersion of nifedipine containing PVP K40000 polymer, showed significant improvement in the drug release profile as compared to nifedipine pure and marketed product. It could be used for the enhancement solubility, dissolution rate and bioavailability of nifedipine.

Keywords: Nifedipine, Solid Dispersion, PEG 6000, Tween-80, PVP.