Abstract: 
Among the other route of drug administration, the oral cavity is an attractive site for the drug delivery of the drugs. However, disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract limits its use for certain drugs. Buccal drug delivery involves the administration of drug through buccal mucosal (the lining in the oral cavity). By the buccal route the drug are directly pass through into systemic circulation, less hepatic metabolism and high bioavailability. The buccal mucosa is very suitable for a bioadhesion system because of a smooth and relatively immobile surface and accessibility. The oral cavity is easily accessible for self medication and can be promptly terminated in case of toxicity just by removing the dosage form from buccal cavity. This drug delivery system utilizes the property of larger surface area and rich blood supply. Certain water soluble polymer become adhesive on hydration and hence can be used for targeting a particular site. Buccal drug delivery prolongs the residence time of dosage form at the site and thus improved the therapeutic performance of drug. This drug delivery also called mucoadhesive drug delivery. It shows better stability, patient compliance, and uniform and sustained drug release. Buccal dosage forms are meant to be placed between gingival and cheek. Buccal adhesive dosage forms are those dosage forms which can deliver drugs either locally to treat conditions within the buccal cavity or systemically via the mucosa

Keywords: Buccal Drug Delivery, Bioadhesion.