Volume 6

January-March 2014

Comparative study of different solubility enhancement techniques and various excipients on solubility and dissolution rate of racecadotril

Vrushali Tambe, Priyanka Bagade, S K Shrivastava

Abstract:
The present investigation envisages effect of various excipients and methods on solubility of Racecadotril which is used as an antidiarrhoeal. Solubility of antidiarrhoeal is paramount important for rapid onset of action. Complexation of drug with Beta-cyclodextrin and Hydroxypropyl Beta-cyclodextrin complexes was done by various methods like physical mixing, kneading, lyophylisation, microwave-irradiation, solvent evaporation and fusion. Mannitol and PEG6000 were used for solid dispersion. To ascertain stability of complexes at various pH, the phase solubility studies were carried out at different pH. Complexes were evaluated by DSC, XRD, SEM and IR. AL type profile was obtained with β-CD and HPβ –CD. The stability constants values are in the range of 100-1000 M-1. β-CD showed greater solubility enhancement as compared to all excipients. Enhancement of dissolution rates with increasing quantity of β-CD in the complex was observed. Complex formation is confirmed using various analytical techniques which primarily may be due to hydrogen bond formation.

Keywords: Racecadotril, Solubility, β-CD, Solvent Evaporation, Fusion.