Development and Characterization of Solid Dispersion of Poorly Soluble Nabumetone Using Locust Bean Gum
Tanuja Sanjay Gurav, Jameel Ahmed S Mulla, Mukesh Vinod Kapse
Abstract:
Solid dispersion (SD) technology is used to increase the solubility and dissolution rate of poorly water-soluble medications. The aim of this study was to enhance the solubility of the poorly water-soluble drug nabumetone (NBT) by utilizing locust bean gum (LBG) as a carrier in solid dispersion (SD) techniques. In the biopharmaceutical industry, Locust Bean Gum as natural polymer is gaining more attention, on the solubility enhancement of the poorly soluble drugs. Poorly soluble nabumetone was selected as an ideal candidate for solid dispersion technique using kneading method. To evaluate the impact of polymer concentration on solubility enhancement, and dissolution experiments were conducted. The solid dispersion was subjected for FTIR, XRD and in vitro release studies. The results demonstrated that NBT’s solubility increased with higher LBG concentrations. Dissolution studies indicated that the Kneading technique is the most practical and effective method for preparing SDs to improve the solubility of NBT. The XRD results confirmed the transition of NBT from a crystalline to an amorphous form in solid dispersion. SD with highest polymer concentration shows the highest solubility, indicates the most potential for improved bioavailability and therapeutic efficacy. In conclusion, LBG shows potential as a carrier to enhance the solubility and dissolution rate of NBT.
Keywords: Nabumetone, Locust Bean Gum, Solid Dispersion, Solubility, Dissolution.
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