Volume 17

January-March 2025

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Development and In Vitro Assessment of Gliclazide-Infused Transdermal Delivery System for the Management of Diabetes Mellitus

Ravindra Laxman Bhedate, Jameel Ahmed S Mulla, Mohammadkaif Javed Nadaf

Abstract:
The primary goals of this study are to create and evaluate transdermal patches loaded with Gliclazide for the treatment of diabetic mellitus. Gliclazide, a class II anti-hyperglycemic drug, has a limited bioavailability (around 40%) and a brief plasma half-life of two to three hours as a result of hepatic degradation. To overcome these limitations, a transdermal drug delivery system (TDDS) was developed using the solvent casting technique. Polyethylene glycol (PEG) was utilised as a plasticiser, and hydroxypropyl methylcellulose (HPMC) and ethyl cellulose were employed as polymers. We evaluated the generated patches’ in vitro drug release, % moisture loss, folding durability, homogeneity in drug content, weight fluctuation, and thickness homogeneity. The thickness of the patches was found to be consistent (0.25 ± 0.05 mm), and the drug content was uniformly distributed. The folding endurance was greater than 150 folds, indicating good flexibility and durability. A cumulative drug release of 76.89% at the conclusion of the study period was demonstrated by in vitro release experiments, which began with an initial burst release and continued for six hours. According to the study, a promising substitute drug delivery method for enhancing Gliclazide’s bioavailability and therapeutic effectiveness in the management of Type II Diabetes Mellitus is the transdermal patch filled with the medication.

Keywords: Transdermal patch, Gliclazide, Diabetes mellitus, Drug release, Bioavailability.

 
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