Volume 4

April-June 2012

Dissolution and bioavailability enhancement of gliclazide by surface solid dispersion using spray drying technique

Hitendra S Mahajan, Ghanashyam A Girnar, Pankaj P Nerkar

Abstract:
The objective of the present study was to formulate surface solid dispersions (SSD) of gliclazide to improve the aqueous solubility and dissolution rate. Gliclazide is a BCS Class II drug having low aqueous solubility and therefore low oral bioavailability. In the present study, SSDs of gliclazide with two different carriers in different drug–carrier ratios were prepared by a spray drying method. Surface solid dispersions were characterized by differential scanning calorimetry (DSC), X-ray diffractometry (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (IR) and evaluated for in vitro dissolution, and relative bioavailability studies using rabbit models. Spray drying resulted in stable and uniformly sized spherical particles of SSDs in comparison to probe sonication as revealed from SEM study. DSC and XRD study demonstrated that there was a significant decrease in crystallinity of pure drug present in surface solid dispersions, which resulted in an increased dissolution rate of gliclazide. Surface solid dispersions showed increase in relative bioavailability than the plain gliclazide suspension. The spray drying would be suitable method for dissolution and bioavailability enhancement of gliclazide.

Keywords: Spray Drying, Gliclazide, Surface Solid Dispersion, Dissolution, Bioavailability.