Volume 10

July-September 2018

Drug delivery and therapeutic ‎approaches to prostate cancer

Jameel Ahmed S ‎Mulla

Abstract: 
According to the global cancer statistics, prostate cancer is the second most often diagnosed cancer in males worldwide and it ranks in fifth place among cancerrelated deaths. Localized prostate cancer is usually treated by surgical removal of the prostate (radical prostatectomy) or by radiation therapy. Both treatment options are frequently associated with severe side effects. Drug delivery to prostate through conventional route is associated with pharmacokinetics based and side effects related problems. This review briefly highlighted about prostate structure and its cancer. Different therapeutic approaches such as radiotherapy, chemotherapy, immunotherapy, androgen deprivation therapy (ADT), focal therapies and systemic therapies; and drug delivery approaches such as liposomes, polymeric based nanoparticles and micelles, dendrimers, gold nanoparticles, carbon based nanoparticles and magnetic nanoparticles for prostate cancer are also outlined here.

Keywords: Prostate Structure, Prostate Cancer, Therapeutic Approaches, Drug Delivery Approaches, Liposomes, Nanoparticles.