Volume 6

January-March 2014

Effect of diluents on immediate release tablet of hydrochlorothiazide

Ujjwala Y Kandekar, P D Chaudhari

Abstract:
The current study is aimed to study the effect of diluents on the immediate release tablet of hydrochlorothiazide. The diluents used are Avicel PH 101 and starlac. Various flow properties are determined for the powder blend and optimised within the range with the help lubricants and glidants. Final bulk is maintained with the help of diluents mainly Avicel PH 101 and starlac. Final tablet are evaluated for various parameters like thickness and diameter, hardness, disintegration time, friability and dissolution rate etc. As the formulation contains diluents in major quantity the effect of these diluents drug release rate is examined. With increase in amount of disintegrating agent release rate is increased up to certain level and then decrease. Release rate of formulations containing Avicel PH 101 is faster as compared to starlac.

Keywords: Avicel PH 101, Starlac, Release Rate.