Volume 6

July-September 2014

Emulgel: A novel approach for topical delivery of hydrophobic drugs

Upadhyayasupriya, Chauhanbisht Seema, Kothiyal Preeti

Abstract: 
Human skin offer ideal and multiple sites to administer therapeutic agent for both local and systemic action. Emulgel is one such emerging topical drug delivery system that incorporates properties of both gel and emulsion and shows dual release control system. The main objective behind emulgel is delivery of hydrophobic drug via skin so that a hydrophobic moiety can enjoy the unique properties of gels. Most of the hydrophobic drugs cannot be incorporated directly into gel base because solubility act as a barrier and problem arises during the release of the drug. Emulgel helps in the incorporation of hydrophobic drugs into the oil phase and then oily globules are dispersed in aqueous phase resulting in o/w emulsion which can be mixed into gel base. Emulgels provide better stability, better loading capacity and controlled release of drug with short half life.

Keywords: Emulgel, Hydrophobic Drugs, Topical Delivery.