Abstract:
Newly synthesized benzopyran-2-one derivatives i.e., 7-(4-hydroxy-3-methoxy benzylideneamino)-4-methyl-2H-chromen-2-one (comp-I), 7-(furan-2-methylene amino)-4-methyl-2H-chromen-2-one (comp-II) and 7-(4-flurobenzyl ideneamino)- 4-methyl-2H-chromen-2-one (comp-III) were assessed for their effects on the convulsant activity by pentylenetetrazole (PTZ) induced seizure model. The results clearly indicated a significant prolongation of onset of seizures and reduced the duration of seizures, where only comp-I was found to be effective in preventing the mortality rate in mice. The anti-convulsant activity was further supported by estimation of serum GABA levels in mice. Comp-I was found to be more potent than comp-II, where as comp-III was less effective as compared to comp- II.

Keywords: Anti-convulsant Activity, Benzopyran-2-one Derivatives, Pentylenetetrazole.