Abstract:
The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. In some cases such as motion sickness, sudden episode of allergic attack, fear of choking and an unavailability of water, the swallowing of tablet or capsules may become difficult. To overcome these difficulties, several fast dissolving drug delivery systems have been developed. Oral fast dissolving film (FDF) rapidly dissolves on tongue releasing the medication readily available for absorption. Domperidone is widely used as antiemetic drug It is also effective in gastro paresis, pediatric gastro esophageal reflux (infant vomiting). In the current work, Ocimum basilicum Gum was employed as a superdisintegrant to assist the flash dissolution of the film. The film was formulated on Film Forming machine by solvent casting method. HPMC was also incorporated in the film for enhancing the properties of the film. The prepared film was evaluated for different parameters. All the formulations of FDF displayed optimum folding endurance above 100 folds. The results were found to be promising ensuring safe and effective dosage form. From the result obtained, it was concluded that the formulation of fast dissolving film has better physical chemical properties with good dissolution property.

Keywords: Domperidone, Ocimum basilicum, Mannitol, Solvent Evaporation Technique.