Abstract:
The microsphere with natural biodegradable polymer creates immense potential for various pharmaceutical applications like mucoadhesive drug delivery via nasal route. Microspheres formulation helps in sustaining the release may be suitable for long term therapy is controlled alleviation of clinical manifestation. The purpose of this research work was to develop optimized and systematically evaluate performances of microspheres of antiemetic drug ondansetron. Alginate microspheres coated with polymer pectin, starch corn were prepared by ionotropic-gelation technique utilizing various cross linking agents. The microspheres obtained were discrete, spherical and free flowing. Alginate microsphere loaded with Ondansetron by using Ionic-gelation technique for control prolonged release of drug. Ondansetron microspheres were formulated by using drug with sodium alginate, pectin and starch in 9 formulations were F₁, F₂, F₃, F₄, F₅, F₆, F₇, F₈ and F₉. All the formulation were investigation for various evaluation parameters like particle size (360 – 280nm), bulk density (0.55 – 0.46 gm/ml),flow behavior, entrapment efficiency (72 – 85%), percentage yield (55 -78 %), and invitro drug release. All the formulation showed good flow behavior. SEM study revealed that the microspheres were almost spherical in shape with smooth surface. In-vitro drug release study showed that by increasing the polymer concentration, decreased drug concentration among all formulations and the optimized formulation (F₃) was able to sustain the drug release for 12 h. So, it was concluded that alginate microspheres loaded with Ondansetron can be prepared by ionic-gelation technique and used for sustaining the drug release for prolong period of time.

Keywords: Ondansetron, Microspheres, Optimized Formulation, Mucoadhesive Drug Delivery.