Abstract:
Mucoadhesive buccal patch of rosuvastatin were prepared by solvent casting technique using 1% hydroxypropylmethylcellulose, and variable amount of polymer sodium carboxymethylcellulose, polyvinyl alcohol (PVA) and polyvinyl pyrrolidine using propylene glycol as plasticizer as well as penetration enhancer. Prepared patch were evaluated for weight uniformity, thickness, surface pH, swelling index, percent moisture absorption, percent moisture lose, folding endurance, in vitro release, and drug content uniformity. The mean thickness of buccal polymeric patches increased with an increase amount of polymer percent. Percent swelling index determined at 5, 10, 30 and 60 minutes increased with time and with increase in hydrophilic polymer. HPMC-SCMC buccal patches show better swelling index because of presence of more hydroxyl group. The increase in the amount of polymer retarded the release of rosuvastatin. F1 (HPMC –SCMC) showed the maximum and faster release. From the study it was concluded that the films exhibited satisfactory swelling, and promising drug release. The formulation was found to be suitable candidate for the development of buccal patches for therapeutic use.

Keywords: Mucoadhesive, Buccal Patch, Rosuvastatin, In Vitro Studies.