Abstract:
The main aim of present study was to build up multiparticulate gastro retentive drug delivery system of Cefuroxime which is used to treat a wide variety of bacterial infections. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria. The gastro retentive drug delivery system can be formulated to enhance the bio-availability of Cefuroxime Axetil by retaining the system into the stomach for extended period of time. Cefuroxime Axetil is a poorly water-soluble drug (BCS Class-II drug) and its bioavailability is exceedingly low. The rate of absorption and the extent of bioavailability for such insoluble drug are restricted by the rate of dissolution in the gastrointestinal fluids. The gastroretentive drug delivery system of Cefuroxime Axetil was primed by emulsion solvent diffusion method by using ethyl cellulose, Eudragit L100, HPMC, Chitosan polymers in changeable concentration. All formulations were evaluated for percent yield, particle size, entrapment efficiency, in vitro buoyancy as well as in vitro release studies. The resultant formulations showed superior buoyancy and in vitro controlled release of Cefuroxime Axetil.

Keywords: Floating Microsphere, Ethyl Cellulose, Hydroxypropylmethylcellulose (HPMC), Eudragit L100, Chitosan.