Abstract: 
The present study was an attempt to develop floating microspheres of captopril to prolong its gastric residence time in stomach. Floating microspheres was formulated using biocompatible polymers like Eudragit S100 and Ethyl cellulose in different proportions by solvent evaporation technique. The prepared microspheres were evaluated for percentage yield, micromeritic properties, particle size, morphology, drug entrapment, buoyancy studies, In vitro drug release studies. Practical yield of the microspheres was up to 76.40%. The formulated microspheres were free flowing with good packing properties. Scanning electron microscopy confirmed spherical structure and the particles were of the size range of 57.66 to 93.21µm. The microspheres with Ethyl cellulose showed higher buoyancy when compared with Eudragit S-100. All formulation showed good in vitro percent buoyancy. In vitro release studies showed cumulative % drug release between 75.95-88.27%. In vitro release studies demonstrated non-Fickian diffusion of drug from the microsphere.

Keywords: Floating Microspheres, Captopril, Eudragit S-100, Ethyl Cellulose.