Abstract:
Bilayer tablets were prepared by using combination of immediate release rabeprazole sodium along with sustained release ketorolac tromethamine. The FTIR study conducted using a combination of drugs along with excipients and polymers revealed that combination can be safely prepared. Rabeprazole sodium was formulated as immediate release layer using sodium starch glycolate, croscarmellose sodium, crospovidone as super disintegrants. The optimized rabeprazole sodium immediate release (IR 9) with highest in-vitro release was selected. Ketorolac tromethamine was formulated as sustained release layer using different grades of HPMC polymers and evaluated for in-vitro release studies. The optimized sustained release layer (F5) was selected. Bilayer tablets were prepared by double compression of optimized ketorolac tromethamine sustained release layer and rabeprazole sodium immediate release layer. All the physical parameters were in acceptable limit of pharmacopoeial specifications. Hence bilayer tablets of ketorolac tromethamine and rabeprazole sodium could be used to improve patient compliance towards the effective management of post operative pain, osteoarthritis without side effect of gastric irritation.

Keywords: Ketorolac Tromethamine, Rabeprazole Sodium, Bilayer Tablets, Immediate Release Layer, Sustained Release Layer.