Volume 12

October-December 2020​

Formulation and evaluation of ‎teneligliptin-loaded mucoadhesive ‎microspheres

Jameel Ahmed S Mulla, Vijayanand R Aralelimath, Omkar Tipugade, Shreyasi S Shinde, Nisha G Tetgure, Ayesha A Mulla, Dinesh D Gavali

Abstract:
The mucoadhesive microspheres are one of the most promising novel techniques for drug delivery. Mucoadhesive systems provide a sustained drug release method, enhancing drug absorption in a site‐specific manner. This study aims to prepare teneligliptin mucoadhesive microspheres to increase the residence time in the gastric and offers control release. The teneligliptin mucoadhesive microspheres are prepared by ionotropic external gelation technique using sodium alginate, HPMC K4, HPMC K15, HPMC K100, xanthan gum, guar gum, and carbopol 934. All mucoadhesive microspheres after preparation were characterized for percentage yield, particle size, drug entrapment efficiency, mucoadhesive test, and in vitro release. The results obtained are differed depending on the concentration of polymers and ratios of drug to polymers.  

Keywords: Diabetes, Teneligliptin, Mucoadhesive, Microspheres, In Vitro Release Study.