Abstract:
The main aim of the current study was to formulate and evaluate microballoons for Telmisartan which is having poor bioavailability. Telmisartan belongs to class II according to BCS classification of drugs, i.e. low solubility and high permeability. The Microballoons for Telmisartan were prepared by emulsion solvent evaporation method using different polymers and their ratios. The polymers include ethyl cellulose and HPMC. The obtained microballoons formulations were evaluated for percentage yield, particle size, buoyancy, drug content in-vitro release studies. The bioavailability of Telmisartan can be increased by formulating it as gastroretentive drug delivery i.e. microballoons. Formulation F4 shows good results with 73.7 % obtained yield, 65.932 % drug content and 75.169 % buoyancy. Microballoons prepared were spherical in size with smooth surfaces concluding it to be optimized formulations.

Keywords: Telmisartan, Emulsion Solvent Evaporation, Buoyancy, Floating Drug Delivery, Gastro Retention.