Abstract:
Microencapsulation is a process by which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of polymeric material. It means of converting liquids to solids, of altering colloidal and surface properties. The capsule protects the active ingredient from its surrounding environment until an appropriate time and material escapes through the capsule wall either by rupture, dissolution, melting or diffusion. In the view of converting the active pharmaceutical ingredients into dosage forms suitable for administration, the present study is an attempt to formulate a hydrogel bead of micron size by ionotrophic gelation technique using potato starch as a release retardant and thereby increasing the release time of the encapsulated drug and providing a delayed/controlled release formulation. It was observed that increase in polymer concentration, the drug release and particle size was gradually decreased. The formulation were investigated for various parameters life particle size, micrometric properties, surface morphology by SEM, incorporate efficiency and in vitro release study. With the obtained results of mentioned parameter it reveals that microbeads with high potato starch concentration (F1 & F2) show delayed release of aceclofenac. Decrease in concentration of alginate results in reduced size of the microbeads along with high efficiency, thus satisfied the need of formulation of delayed release aceclofenac microbeads.

Keywords: Microencapsulation, Aceclofenac, Potato Starch, Alginates, SEM.