Abstract:
Introduction: Medicated Chewing Gum is considered as vehicle or drug delivery system to administer active principles that can improve health and nutrition. It is a novel drug delivery system containing masticatory gum base with pharmacologically active ingredient and intended to use for local treatment of mouth diseases or systemic absorption through oral mucosa. The buccal route of drug administration also has important advantage of direct access to the general circulation and overcomes the first pass hepatic metabolism. Methods and Materials: The aim of present study was to design and characterise Medicated Chewing Gum for the treatment of bacterial infection using Amoxicillin Trihydrate as model drug. The chewing gums were prepared using Health in Gum grade01(HiG-01) as a directly compressible gum base developed by Cafosa (S.A.U.), Spain. The effect of concentration of (Base) Gum Base, (release modifier) Aerosil, and (antiadherant) talc was studied. Result and discussion: The dissolution study showed that optimum amount of Gum Base shows superior result. Amoxicillin Trihydrate is an antibacterial agent. After oral administration it is rapidly absorbed. Maximum peak plasma concentration is reached after approximately 1 hr this model drug is selected for the study in order to overcome the hepatic first-pass effect and there by possible reduction in the dose. The drug is tasteless so there was no issue with taste masking. Amoxicillin Trihydrate has higher oral bioavailability, less side effects and has short duration of action of about 1.02 hr; these factors make Amoxicillin Trihydrate is suitable candidate for formulation of medicated chewing gum used to treat bacterial infection.

Keywords: Medicated Chewing Gum (MCG), Health in Gum-01, Amoxicillin Trihydrate.