Abstract:
The present study was aimed at investigating hepatoprotective activity of different extracts of leaves of Ervatamia heyneana with a view to justify the use of the plant. The various extracts of leaves of Ervatamia heyneana were obtained by successive soxhlation with petroleum ether (60 – 80°C), chloroform, ethyl acetate, methanol and water for 6 hours. The dried extracts of leaves (Petroleum ether, methanol and aqueous) were used for hepatoprotective activity against carbon tetra chloride induced liver damage in albino rats. Various biochemical parameters were studied to evaluate the hepatoprotective activity of the extracts for total bilirubin (TBL), alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein (TPL) and albumin levels (ALB). This study revealed that aqueous extract (500mg/kg) showed significant activity which was comparable to that of standard drug silymarin (100mg/kg). Aqueous extract (500mg/kg) was found to protect the rats from hepatotoxic action of carbon tetra chloride as evidenced by significant reduction in the elevated serum enzyme levels. Histopathological studies showed regeneration of hepatocytes of the extract treated liver samples which stipulate its hepatoprotective activity.

Keywords: Ervatamia heyneana, Carbontetrachloride, Hepatoprotective Activity.