Abstract: 
Oral administration of aqueous extract of Elephantopus scaber leaves (300 mg/kg body weight) and roots (300 mg/kg body weight) for 84 days significantly reduced serum glucose, glycosylated hemoglobin and the activity of gluconeogenic enzyme glucose-6-phosphatase, but increased serum insulin, liver and skeletal muscle glycogen content and the activity of glycolytic enzyme glucokinase. The light microscopic studies of the pancreatic section of rats administered with the aqueous extract of of Elephantopus scaber leaves and roots showed an improvement in the histoarchitechture. For all the biochemical and histological studies performed, Elephantopus scaber roots treated rat showed a little better activity than Elephantopus scaber leaves treated diabetic rats. The present investigation suggests that Elephantopus scaber leaves and roots extract exhibit antihyperglycaemic effects and consequently may alleviate damage of pancreas and liver associated with alloxan-induced diabetes mellitus in rats.

Keywords: Alloxan, Diabetes Mellitus, Elephantopus Scaber, Glucose, Insulin, Light Microscopy.