Volume 9

July-September 2017

Investigation of impact of mechanochemical approach on solubility and dissolution rate enhancement of poorly water soluble febuxostat

Vishal V Pande, Surekha Jamdhade, Gayatri V Dusane, Priyanka P Salunke, Nikita A Borawake, Prakash N Kendre

Abstract:
The aim of present study was to increase the solubility and dissolution of poorly water soluble Febuxostat by mechanochemical approach. Initially the drug was milled in planetary ball mill and then particle size of milled Febuxostat was measured by Malvern zetasizer, hence the particle size of milled Febuxostat was reduced 4.4% as compare to plain unmilled drug 2%. The solid dispersions of poorly water soluble Febuxostat was prepared with water soluble carrier such as gelucire 44/14 and aeroperl 300 was added as adsorbent to improve its solubility and dissolution properties. The solid dispersions of different ratios i.e., 1:1, 1:2, 1:3 and 1:4 of milled and unmilled Febuxostat were prepared by particle size reduction by planetary ball mill and melt method. Characterization of solid dispersions of milled and unmilled was performed using FTIR, DSC, PXRD, SEM, solubility and dissolution study.

Keywords: Febuxostat, Mechanochemical Approach, Solid Dispersions.