Abstract:
Controlled release matrix tablets of Ciprofloxacin HCl were prepared and evaluated as the function of varying the concentrations of polymers e.g., Povidone K-30 and excepients e.g, Avicel pH 101. The concentrations were varied to investigate whether these variations can cause any change in release of Ciprofloxacin HCl molecule. Tablets were prepared by direct compression method. The granules were evaluated for drug content and drug excipient interaction. The tablets were subjected to thickness, diameter, hardness and in vitro release studies. The USP Basket method was selected to perform the dissolution test carried out in 1000 ml 0.1 N HCl for 8 hours with 50 rpm, at 37±0.5°C.The release rate was quantitatively determined by a UV-spectrophotometeric method. By comparing the dissolution profiles, it is revealed that significant differences were found among the drug release profile from different formulations matrices. From the study it is found that, Povidone K-30 based matrix tablets release greater percentage of active drug with incorporating the increasing amount of Avicel pH 101. The release of active drug from the prepared matrix tablet appears to follow the Higuchi kinetics model. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism was diffusion controlled or Fickian transport which was only dependent on the type and amount of polymer used. The drug release followed both diffusion and erosion in all cases.

Keywords: Matrix Tablets, Ciprofloxacin HCl, Povidone K-30, Avicel pH 101.