Network Pharmacology Approaches for Drug Discovery and Repositioning: An Evolving Paradigm
Supriya Sarkar, Rojina Khatun, Sudeshna Sengupta, Malavika Bhattacharya
Abstract:
Network-based on drug discovery and existing drugs is a new method that employs systems biology and computational tools to analyze complicated biological networks. In the case of traditional single-target drug discovery, this aspect concentrates on considering how molecules interconnect within the whole network of proteins, genes, and pathways, taking into account disease mechanisms. It authorizes researchers to recognize original therapeutic uses for developing multi-target treatments for diseases with intricate mechanisms, such as cancer or neurodegenerative disorders, and existing drugs (drug repurposing). By using advancements in data analytics and artificial intelligence, this offer holds high potential for revolutionizing drug discovery and accelerating personalized medicine. However, future challenges, specifically computational complexities and incomplete data, remain to be discovered.
Keywords: Network Pharmacology, Systems Biology, Drug-target Interaction Networks, Gene Regulatory Networks, Signaling Pathways, Omics Data Integration.
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