Next – Generation Drug Delivery System: Bridging Innovation and Therapeutic Needs
Prathamesh Nivas Thorat, Jameel Ahmed S Mulla, Milind Dilip Phanse
Abstract:
“Next-Generation Drug Delivery Systems: A Controlled Release Concept” is a groundbreaking book, self-contained and fully integrated in its treatment of next-generation nano systems employed in controlled release of drugs.” Through implementation of nanotechnology, biomaterials technology, 3D printing, microfluidic device technologies and AI guidance models as well as precision medicine methodology incorporated NGDDS could provide the controlled and targeted delivery along with personalized patient specific treatment. Biocompatible, biodegradable, and active/passive targeting capabilities along with controlled release and stimuli-responsiveness are core design features for intelligent carriers such as nanoparticles, liposomes, polymeric micelles, hydrogels, microneedles, implantable systems and bioinspired vesicles. They improve the pharmacokinetics, stabilise fragile biologics and enable programmable site-specific release of drug in situ. Therapeutic uses range from oncology, neurological diseases and infectious endemics (e.g., m RNA based vaccines), to autoimmune disorders and gene/nucleic-acid therapies. But there are still hurdles to overcome in the areas of mass production, long-term safety, biodistribution, immunogenicity and regulatory complexity. Novel trends including personalized nanomedicine, combined with digital health and wearable sensors, green biomaterials and ethical consideration are paving the way for NGDDS in a new direction. In general, NGDDS represent a revolution by bringing technological discoveries to meet medical challenges in the context of predictable, preventive, personalized, and participatory (P4) medicine that are more accurate, safer and cheaper overall.
Keywords: Next-Generation Drug Delivery Systems (NGDDS), Controlled Release, Nanotechnology, Biomaterials Technology, 3D Printing, Microfluidic Devices, AI Guidance Models, Precision Medicine, Personalized Drug Delivery, Biocompatible Carriers, Biodegradable Systems, Targeted Delivery.
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