Abstract:

Niosomes are vesicles that are created by hydrating a mixture of lipids that are biodegradable, non-ionic surfactant, and cholesterol. In comparison to a drug’s traditional dosing form, niosomes boost the drug’s action. Drugs that are amphiphilic or lipophilic can be transported via niosomes. The problems associated with pharmaceutical instability, rapid disintegration, insolubility, and low bioavailability may be resolved by niosomes. The manner of formulation determines whether niosomes are multilamellar or unilamellar in structure. For the site-specific administration of anti-cancer, anti-infective drugs, etc., niosomes have a very effective drug delivery capability. In comparison to other drug formulations, niosomes are stable and inexpensive carriers. Niosomes are also used in innovative drug delivery systems, topical drug delivery systems, oral drug delivery systems, and parental drug delivery systems. This review provides an extensive summary of niosomal studies to date, as well as a detailed look at formulation aspects, niosome types, physical characterization methods, and recent pharmaceutical applications like transmucosal, oral, ocular, topical, and pulmonary drug delivery as well as cosmetic applications.

Keywords: Non Ionic Surfactant Vesicle, Niosomes, Preparation, Characterization, Applications.