Volume 9

October-December 2017

Preparation and characterization of voriconazole solid lipid nanospheres

Somayeh Brahimi, Tayebeh Toliyat

Abstract:
Voriconazole is an antifungal drug used for treatment of various conditions caused by yeast or fungi. Voriconazole is changed form of flouconazole and it is improved potency and spectrum. In this study, we prepared voriconazole as solid lipid nanoparticles (SLN) using the melting method. Stearic acid, palmitic acid and glyceryl monostearate were selected as lipid carriers based on drug solubility and partitioning behaviour. Poloxamer and soya lecithin were the choice for surfactant. The particle sizes of the SLNs determined by zeta sizer. The in vitro release study of SLNs exhibited a sustained-release property of the drug. The effect of various lipids on capture volume, particle size and drug release of these particles were studied. The results show that the presence of glyceryl monostearate as lipid phase has significant effects on the size of particles. In Vitro release performed in phosphate buffer (pH=7.4) by using dialysis bags. It can be assumed that drug release from SLNs is following biphasic model and the first phase is followed the first order equation.

Keywords: Voriconazole, Solid Lipid Nanospheres, Physicochemical Characterization, In Vitro Release Study.