Abstract:
The aim of the present investigation is to prepare mefenamic acid loaded Eudragit microsphere by solvent evaporation technique. Total seven formulations were prepared by altering drug to polymer. The obtained microspheres were evaluated for drug content, entrapment efficiency, loading capacity and surface morphology. In vitro dissolution profile of all the seven formulation was compared. Among all the formulations F3 formulation was found to be the best formulation with a product yield pf 83%, drug content of 87%. The entrapment efficiency and loading capacity was observed as 93% and 79% respectively. In a time period of 12 hrs 98.5% of drug was released from F3 formulation.

Keywords: Mefenamic Acid, Eudragit, Microsphere, Solvent Evaporation Technique.