Abstract: 

Solid lipid nanoparticles (SLN) have been established as an alternative particulate carrier system. Recently, increasing attention has been focused on these SLN as colloidal drug carriers combining advantages of polymeric nanoparticles, fat emulsions, and liposomes, but simultaneously avoiding some of their disadvantages. Under optimized conditions, SLNs can be produced to incorporate lipophilic or hydrophilic drugs and seem to fulfill the requirements for an optimum particulate carrier system. This review describes the characterization of SLN such as particle size, zeta potential, surface morphology, lipid crystallinity, rheological properties etc.

Keywords: Solid Lipid Nanoparticles, Particle Size, Zeta Potential, Differential Scanning Calorimetry.