Abstract: 
This investigation explores use of Oleic acid, Tween 80 and Transcutol HP in self emulsifying pellets of nevirapine with enhanced solubility and dissolution efficiency. Liquid SEDDS was prepared and characterized by self emulsification time, precipitation, thermodynamic stability, globule size, PDI, zeta potential. Self emulsifying pellets were characterized by surface topography, flow properties, disintegration time, in vitro drug release and stability. Optimized SEP6 had disintegration time (7 ± 2 min) and % dissolution efficiency about 86.22 ± 1.25 for 1 h. In conclusion, self emulsifying pellets of nevirapine could be demonstrated as new approach to enhance its solubility and dissolution efficiency.

Keywords: Nevirapine, Lipophilicity, Self Emulsifying Pellets, Dissolution Efficiency.