Abstract:

A series of 5,6-disubstituted imidazo[2,1-b][1,3,4]thiadiazoles were synthesized. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the title compounds were tested for their in-vitro antitubercular activity against Mycobacterium tuberculosis H₃₇Rv using AlamarBlue susceptibility test, and the activity is expressed as the minimum inhibitory concentration (MIC) in μg/mL. Among the series, compounds 3a, 3c, 4a, 5c and 6a displayed an encouraging antitubercular activity profile as compared to the reference drug, rifampicin.

Keywords: imidazo[2,1 -b][1,3,4]thiadiazole, Mannich Reaction, Antitubercular Activity.