Volume 16

July-September

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Unlocking Nanosponges Potential: An Overview of Formulation Strategies, Assessment Approaches and Emerging applications

Priyanka Jadhav, Jameel Ahmed S. Mulla

Abstract: 
Nanotechnology, a multidisciplinary field, has emerged as a transformative force in various industries, particularly medicine. Among its innovations, nanosponges stand out as a promising class of nanomaterials, distinguished by their porous, sponge-like structures. Typically synthesized through the cross-linking of cyclodextrins, nanosponges exhibit remarkable capabilities in drug administration and diagnostics because of their capacity to encapsulate diverse molecules. These properties enable enhanced solubility, controlled release, and targeted delivery. Nanosponges are fabricated using various techniques, such as quasi-emulsion solvent diffusion, ultrasound-assisted synthesis, and melt methods, each influencing their particle size, surface charge, and drug-loading capacity. These methods ensure reproducibility, scalability, and compliance with regulatory standards. Evaluation methods like thermo-analysis, microscopy, zeta potential, and particle size determination further affirm their efficiency and compatibility. They also find applications in diagnostics, serving as biosensors and imaging agents, and in theranostics for simultaneous disease detection and treatment. Additionally, they hold potential in gene delivery, tissue engineering, and vaccine development.Future research aims to address these issues and explore novel applications, positioning nanosponges as a pivotal tool in advancing healthcare and biomedical technologies.

Keywords: Nanosponges, Cyclodextrins, Controlled release, Targeted delivery.

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