Volume 17, Issue 4, Oct-Dec 2025

Volume 17

October-December 2025

Solid Lipid Nanoparticles as Drug Carriers: Design and Applications of Programmable Nanoparticulate Delivery Systems

Prerana Shivaji Kadam, Jameel Ahmed S Mulla, Viraj Atul Mahajan

Abstract:
(SLNs) or Solid Lipid Nanoparticles: These are very small balls of safe fats that help transport medicines throughout the body. These tiny fat particles can serve to shield the drug, help it work better and last longer in the body. They’re formulated with all-natural lipids, and safe helpers called surfactants and co-surfactants help keep them stable so they don’t glob together. Various strategies, such as heating, mixing and cooling, are exploited by the scientists to fabricate SLNs in the correct size and shape. The nanoparticles can deliver drugs through the mouth, skin, eyes and nose, in addition to by means of injections into the blood or lungs. They already serve as treatment for many diseases, including cancer, infections and brain disorders. The newer vehicle, such as SLN are far superior than older vehicle in term of being biocompatible and less toxic, cost effective and slow and sustained release of drug. Occasionally, however, drugs can leak or degrade while in storage. These days, scientists are designing smarter SLNs with the help of new concepts such as green technology and artificial intelligence. In the future, those smart SLNs could be used for vaccines and special treatments to help people heal faster and stay healthy.

Keywords: Drug Delivery, Lipids, Surfactants, Encapsulation Efficiency, Particle Size, Zeta Potential, Controlled Release, Oral Delivery, Ocular Delivery, Pulmonary Delivery, Parenteral Delivery, Anticancer, Antiviral, Anti-inflammatory, CNS Targeting.

A Review of Artificial Inspiration in Drug Delivery Systems

Kiran B Dhamak, Akshata Pagar, Vinayak M Gaware

Abstract:
By making therapy more precise, effective, and individualized, artificial intelligence (AI) is revolutionizing medication delivery methods. AI helps with drug design, controlled release, dose optimization, and targeted administration through machine learning, deep learning, and natural language processing. We are able technology, biosensors and nanotechnology integration provide adaptive therapies and real-time monitoring, while patient-specific modelling improves personalized medicine. Autonomous drug delivery systems, digital twins, intelligent Nano carriers, and other future advancements are all possible using AI-driven platforms, despite issues with data quality, ethics, regulation, and cost. This change in perspective has the potential to transform pharmaceutical treatment and enhance therapeutic results. This study provides a comprehensive overview of scientific advancements over the last ten years with the goal of igniting interest in the incorporation of various forms of artificial intelligence in AM and MFs as crucial methods for improving the quality standards of customized medicinal applications and lowering variability potency throughout a pharmaceutical process.

Keywords: Artificial Intelligence, Biosensors Machine, Drug Delivery System, Learning, Deep Learning, Personalized Medicine, Patient Specific Modelling, Pharmacogenomics.

A Review on Floating In-Situ Gel: A Promising Strategy for Prolonged Gastric Retention and Controlled Drug Release

Aniket Anand Nale, Jameel Ahmed S Mulla

Abstract:
Drugs that have limited absorption windows or poor gastrointestinal tract stability may benefit from the use of floating drug delivery systems (FDDS), which have shown promise in increasing bioavailability and therapeutic efficacy. In situ gels, which gel when they come into touch with stomach secretions, provide a number of benefits, including regulated medication release and an extended period of stomach retention. The development, workings, and advantages of floating in situ gel systems are examined in this paper. It highlights the polymers utilized in these systems and talks about the different ways that gel formation can be achieved, such as pH modification, temperature modulation, and ionic crosslinking. The review also discusses the therapeutic implications and prospective benefits of FDDS in the future for enhancing treatment outcomes and patient compliance.

Keywords: Floating Drug Delivery Systems, Gastro-Retentive Drug Delivery, In-Situ Gel, Controlled Release, Bioavailability Enhancement, Therapeutic Efficacy.

Next – Generation Drug Delivery System: Bridging Innovation and Therapeutic Needs

Prathamesh Nivas Thorat, Jameel Ahmed S Mulla, Milind Dilip Phanse

Abstract:
“Next-Generation Drug Delivery Systems: A Controlled Release Concept” is a groundbreaking book, self-contained and fully integrated in its treatment of next-generation nano systems employed in controlled release of drugs.” Through implementation of nanotechnology, biomaterials technology, 3D printing, microfluidic device technologies and AI guidance models as well as precision medicine methodology incorporated NGDDS could provide the controlled and targeted delivery along with personalized patient specific treatment. Biocompatible, biodegradable, and active/passive targeting capabilities along with controlled release and stimuli-responsiveness are core design features for intelligent carriers such as nanoparticles, liposomes, polymeric micelles, hydrogels, microneedles, implantable systems and bioinspired vesicles. They improve the pharmacokinetics, stabilise fragile biologics and enable programmable site-specific release of drug in situ. Therapeutic uses range from oncology, neurological diseases and infectious endemics (e.g., m RNA based vaccines), to autoimmune disorders and gene/nucleic-acid therapies. But there are still hurdles to overcome in the areas of mass production, long-term safety, biodistribution, immunogenicity and regulatory complexity. Novel trends including personalized nanomedicine, combined with digital health and wearable sensors, green biomaterials and ethical consideration are paving the way for NGDDS in a new direction. In general, NGDDS represent a revolution by bringing technological discoveries to meet medical challenges in the context of predictable, preventive, personalized, and participatory (P4) medicine that are more accurate, safer and cheaper overall.

Keywords: Next-Generation Drug Delivery Systems (NGDDS), Controlled Release, Nanotechnology, Biomaterials Technology, 3D Printing, Microfluidic Devices, AI Guidance Models, Precision Medicine, Personalized Drug Delivery, Biocompatible Carriers, Biodegradable Systems, Targeted Delivery.

Formulation and Evaluation of NabumetoneEmulgel for Topical Drug Delivery

Rashmi B Surekar, Twarita D Deshpande, Onkar V Jadhav, Anuj J Shinde

Abstract:
Nabumetone is commonly used to relieve pain and inflammation, especially in conditions like arthritis. However, its use through oral administration poses certain difficulties. These include its poor solubility in water, which limits its absorption, and a tendency to irritate the gastrointestinal tract, which may lead to discomfort or other side effects in patients. To overcome these limitations, the present investigation focused on developing a topical emulgel formulation. Carbopol 934 and Hydroxypropyl Methylcellulose K15M (HPMC K15M) were employed as gelling agents, and their concentrations were systematically varied to assess their influence on the drug release profile. Emulsion systems were systematically developed using light liquid paraffin as the oil component, Tween 80 as the primary surfactant, and an appropriate co-surfactant. To identify the optimal emulsification zone, pseudoternary phase diagrams were constructed and analyzed. The final emulgel was prepared by incorporating the optimized emulsion into gel bases containing different concentrations of the gelling agents (1.5%, 2.0%, and 2.5%). Comprehensive evaluation of the formulations indicated that the optimized batch, F2, exhibited favorable physicochemical stability in terms of pH, viscosity, and cumulative drug release percentage under ambient and accelerated storage conditions.

Keywords: Nabumetone, Emulgel, Topical Delivery, Rheumatoid Arthritis, Emulsion.

Indian Journal of

Novel Drug Delivery

NMC Approved Journal

ISSN 0975-5500