Volume 17

October-December 2025

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Solid Lipid Nanoparticles as Drug Carriers: Design and Applications of Programmable Nanoparticulate Delivery Systems

Prerana Shivaji Kadam, Jameel Ahmed S Mulla, Viraj Atul Mahajan

Abstract: 
(SLNs)  or Solid Lipid Nanoparticles: These are very small balls of safe fats that help transport medicines throughout the body. These tiny fat particles can serve to shield the drug, help it work better and last longer in the body. They’re formulated with all-natural lipids, and safe helpers called surfactants and co-surfactants help keep them stable so they don’t glob together. Various strategies, such as heating, mixing and cooling, are exploited by the scientists to fabricate SLNs in the correct size and shape. The nanoparticles can deliver drugs through the mouth, skin, eyes and nose, in addition to by means of injections into the blood or lungs. They already serve as treatment for many diseases, including cancer, infections and brain disorders. The newer vehicle, such as SLN are far superior than older vehicle in term of being biocompatible and less toxic, cost effective and slow and sustained release of drug. Occasionally, however, drugs can leak or degrade while in storage. These days, scientists are designing smarter SLNs with the help of new concepts such as green technology and artificial intelligence. In the future, those smart SLNs could be used for vaccines and special treatments to help people heal faster and stay healthy.

Keywords: Drug Delivery, Lipids, Surfactants, Encapsulation Efficiency, Particle Size, Zeta Potential, Controlled Release, Oral Delivery, Ocular Delivery, Pulmonary Delivery, Parenteral Delivery, Anticancer, Antiviral, Anti-inflammatory, CNS Targeting.

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