Abstract: 
Chronotherapeutics is the purposeful timing of medications, with or without the utilization of special drug-release technology, to proportion serum and tissue concentrations in synchrony with known circadian rhythms in disease processes and symptoms as a means of enhancing beneficial outcome sand/or attenuating or averting adverse effects. The concept of chronotherapeutics, although relatively new to hypertension and cardiovascular medicine, was first introduced and proven worthy in clinical medicine in the 1960s; the morning alternate-day corticosteroid tablet dosing schedule was introduced as a convenient means of minimizing the adverse effects of such anti-inflammatory medications as prednisolone and methylprednisolone. The chronotherapy of hypertension takes into account the clinically relevant features of the 24-hour pattern of blood pressure (BP) (i.e., the accelerated morning rise at the commencement of diurnal activity and the extent of decline during nighttime sleep) plus potential administration-time (circadian rhythm) determinants of the pharmacokinetics and dynamics of individual antihypertensive medications. Herein, we focus on the chronotherapy of hypertension; however, as necessary background we first present the major concepts and mechanisms of biologic timekeeping

Keywords: Chronotherapy, Biological Rhythm, Circadian Rhythm.