Abstract: 

Transdermal drug delivery is a forward-looking approach which complements the constraints of standard drug delivery systems such as oral and injectable techniques. This delivery path enables both easy and painless delivery of drugs and a continuous release profile. Ethosomal hydrogel or Nano hydrogel is an innovative approach for transdermal drug delivery system which combines the benefits of both hydrogel as well as ethosome in delivery of drugs. Hydrogels are relatively similar to natural tissue as they possess a degree of flexibility  due to their significant high water content and also helps in skin hydration which is one of the most significant factors in determining percutaneous absorption  rate of a given drug molecule. Using carriers system, such as ethosomes have demonstrated promising results in transdermal drug delivery capable of delivering drugs to the deeper skin tissues more effectively and efficiently. This review highlights and presents an overview on ethosomal-loaded hydrogel, method of preparation, characterization, evaluation and application ethosomal hydrogel in transdermal drug delivery.

Keywords: Transdermal Drug Delivery System (TDDS), Hydrogel, Ethosome, Ethosomal-Loaded Hydrogel, Cross-Linking.