A new topical application for hydrogel composite based on sodium carboxymethyl cellulose with bee pollen for second degree burns in adult rabbits
Salima Bacha, Hadj Benhebal, Mohamed Hamdi, Moussa Ahmed, Baghdad Khiati
Numerous previous studies have demonstrated improved wound healing associated with natural-based formulations. Therefore, in the present work, a hydrogel composed of biopolymer gelatin incorporated with bee pollen was chosen to develop BPHG of healing in second degree burn wounds in adult rabbits. A total of 09rabbits with superficial and partial thickness burns were divided into three equal groups randomly by consecutive sampling method, one group were dressed with BPG while the other was treated with paraffin-impregnated tulle gras (PTG). Adult rabbits were anesthetized and dorsum shaved. Cylindrical stainless-steel rod (2×4 cm diameter) was heated to 100℃. Additionally the bee pollen powder used has been characterized by FTIR spectroscopy. On Day 25, Only in the BPHG-treated groups, was degree of wound healing increased up to normal condition. Besides, the healing area of the BPHG-treated wound was better than that of the untreated and PTG- treated groups during 2, 14 and 14 days after burn. In this first approach with BPGH our results provide the first demonstration that bee pollen gel can be considered as a possible alternative for the treatment of burns.
Keywords: Bee Pollen, Na CMC, Burn.