Volume 8

January-March 2016

Design and characterization of eudragit coated floating microsphere of clarithromycin prepared by emulsion solvent diffusion

Shrishail M Ghurghure, Deepak P Pawar

Abstract:
In the present study, an attempt has been made to prepare floating microspheres of clarithromycin designed as gastroretentive dosage form for the treatment of Heliobacter pylori. To develop oral drug delivery systems, it is necessary to optimize both the residence time of system within the gastrointestinal tract and release of drug from the system. The floating microsphere is prepared by the emulsion solvent evaporation method. Formulations were characterized for their particle size, practical yield, entrapment efficiency, in vitro buoyancy, scanning electron microscopy (SEM) and in vitro drug release. Scanning electron microscopy shows that spherical microspheres with porous surface were formed. The In-vitro release was significantly decreased with increase in polymer concentration.

Keywords: Heliobacter pylori, Clarithromycin, In -vitro Buoyancy, SEM, In- vitro Release.