Volume 8

January-March 2016

Review Articles

Ajay Kumar, Jashanjit Singh

From the ancient times, wound healing without infection has been main challenge in the field of medical science. For effective healing of a wound, a suitable material had to be used to cover the wound in order to prevent any infection. People have been trying various wound healing processes and material from natural extracts to synthetic implants. Various novel pharmaceutical preparations namely gels, hydrogels, spray, foams, composites and porous film membranes are available for better wound care and healing. Porous scaffolds have many advantages like hemostasis, absorbability, semi-permeability, conformability and scar free over the conventional wound healing materials. Porous scaffolds are easy to formulate and can also be easily sterilized depending upon the area of use. The current review emphasis on the use, method of preparation and advantages of various porous scaffolds fabrication techniques. With the continuous dedicated research in this field the future in near when prous scaffolds would be available as a simple film and would be in the reaches of every individual. This would improve the quality of wound healing with proper concern and care.

Keywords: Wound Dressing, Wound Healing, Porous Scaffolds, Solvent Casting, Melt Moulding.

Research Articles

Shittu A O, Adebayo L A

This research was conducted to isolate and purify “LOCUST BEAN GUM” (LBG) from locust bean seeds. It was investigated as a potential binder in paracetamol (PCM) tablets. The Locust bean gum was extracted by a standard method. The gum was extracted using ethanol (analytical grade). The viscosity of LBG at 0.5, 1.0, 1.5 and 2.0 %w/v were found to be: 62, 80, 90, and 105 mPa.S-1) respectively. The physicochemical properties of various batches of PCM granules showed fair flowability and compressibility. The granule size percent cumulative showed average granule size for granules having LBG and AG binder at 500 µm, while that of gelatin was located at 755 µm. Both LBG and AG formed softer tablet compared with gelatin. The LBG was used as binder to formulate the paracetamol tablets by wet granulation method at varying concentration of the gums ranging from 0.25, 0.50, 0.75 and 1.00 %w/v (F1 to F4), (acacia gum as binder,F5 to F8; gelatin as binder, F9–F12) using a single punch tablet machine compressed at compression 2.0 KN and punch and die size 12 mm. Evaluation of paracetamol tablet yielded tablets with lower crushing “44 N and 45 N” for F3 and F4 respectively (LBG as binder at concentration of 0.75 and 1.0 %w/v respectively) compared with F7 and F8, “52 N and 53 N” respectively (acacia gum as binder at the same concentration as former) and, F11 and F12 “101 N and 110 N” respectively (gelatin as binder also as former).The friability values for F3, F4, F7, F8, F11, and F12, are as follow: 1.41, 1.22; 1.20, 1.11; 1.04 and 1.02 % respectively. LBG and AG, both formed tablets relatively less compact compared with gelatin. The disintegration times for the same batches are in the following order: 27, 28, 30, 31, 60 and 75 min respectively. The results indicate that “LBG” is a good binder in terms of crushing strength, friability and disintegration time. In conclusion, locust been gum is relatively as good as acacia gum in formulating conventional tablets with wet formulation method.

Keywords: Locust Bean Gum, Binder, Seed Gum, Wet Granulation.

Kotta Kranthi Kumar, Pankaj Kumar Sharma, L Srinivas

Irbesartan was practically insoluble in water. The aim of the present work is to increase the solubility of drug and bioavailability without modifying the properties of drug. In this present work solubility was increased by spherical crystallization method and converted into a tablet. Various solvents like N, N dimethyl formamide as a good solvent, bridging solvent chloroform & bad solvent water were selected. Spherical crystals are prepared by using β-cyclodextrin and HP-β-cyclodextrin in various ratios by quasi emulsion solvent diffusion method. Spherical agglomerates are prepared and converted into orodispersible tablets by direct compression technique. Various super disintegrating agents (SSG and Croscarmalose and crospovidone) batch F36 of 1:3 rations shown high dissolution efficiency of 98.09% and when compared with the marketed product shown better dissolution value. NOVA significance value of P<0.05 which will indicates the co-processing parameters variability within the specified limits. F36 shown higher plasma concentration which will indicates the increased bioavailability. When F36 batch execute in pilot plant scale will increases the production rate and available the tablet in affordable cost to the poor people.

Keywords: Irbesartan, β-cyclodextrin, HP-β-cyclodextrin, SSG, Croscarmalose.

Shrishail M Ghurghure, Deepak P Pawar

In the present study, an attempt has been made to prepare floating microspheres of clarithromycin designed as gastroretentive dosage form for the treatment of Heliobacter pylori. To develop oral drug delivery systems, it is necessary to optimize both the residence time of system within the gastrointestinal tract and release of drug from the system. The floating microsphere is prepared by the emulsion solvent evaporation method. Formulations were characterized for their particle size, practical yield, entrapment efficiency, in vitro buoyancy, scanning electron microscopy (SEM) and in vitro drug release. Scanning electron microscopy shows that spherical microspheres with porous surface were formed. The In-vitro release was significantly decreased with increase in polymer concentration.

Keywords: Heliobacter pylori, Clarithromycin, In -vitro Buoyancy, SEM, In- vitro Release.

A Krishna Sailaja, M Nandini

The aim of the present investigation is to prepare diclofenac loaded BSA nanoparticles by desolvation technique using acetone as desolvating agent. Two formulations were prepared by using continuous addition method and intermittent addition method. Process parameters such as stirring speed and stirring time were optimized. Both the formulations were evaluated for particle size, zeta potential, drug content, entrapment efficiency and loading capacity. Intermittent addition method was showing less mean particle diameter, high drug content, highest entrapment efficiency and loading capacity than continuous addition method. Based on the results it was concluded that intermittent addition method was found to be better than continuous addition method for preparing diclofenac nanoparticles.

Keywords: Diclofenac Sodium, BSA, Glutaraldehyde, SEM, Zeta Sizer.

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