Abstract:
The aim of the present investigation is to prepare diclofenac loaded BSA nanoparticles by desolvation technique using acetone as desolvating agent. Two formulations were prepared by using continuous addition method and intermittent addition method. Process parameters such as stirring speed and stirring time were optimized. Both the formulations were evaluated for particle size, zeta potential, drug content, entrapment efficiency and loading capacity. Intermittent addition method was showing less mean particle diameter, high drug content, highest entrapment efficiency and loading capacity than continuous addition method. Based on the results it was concluded that intermittent addition method was found to be better than continuous addition method for preparing diclofenac nanoparticles.

Keywords: Diclofenac Sodium, BSA, Glutaraldehyde, SEM, Zeta Sizer.