Volume 16, Issue 1, Jan-Mar 2024

Volume 16

January-March 2024

Smart Polymers for Smart Medicine: Unravelling the Role of Polymers in Drug Delivery

Pankaj Mhatre, Kedar Bavaskar, Rutuja Sawant, Ashish Jain

Abstract:
Over the last few decades, after much research, several interesting characteristics and potential uses for polymers have been discovered. The current review focuses on the role of polymers in the pharmaceutical dosage forms such as in tablets, controlled release dosage forms, polymeric nanoparticles, tissue engineering, gene delivery, ocular drug delivery and many other novel drug delivery systems. In various dosage forms and drug delivery systems, the use of polymer results in drug release that is sustained, extended, modified, controlled, and targeted. An overview of pharmaceutical polymers, covering their properties, classification, drug release mechanism, and applications in drug delivery systems, is presented in this article. The aim of this article is to provide a wide-angle prospect of the different uses of pharmaceutical polymers in pharmaceutical drug delivery. The several types of polymeric excipients are discussed, with special attention paid to how they work in oral delivery of drug. to completely exploit their various qualities and possible impact on medication delivery in an effort to create better pharmaceutical goods overall.

Keywords: Polymers, Controlled Drug Release, Pharmaceutical Excipient, Drug Delivery.

Hyaluronic Acid-Coated Niosomes: A Promising Drug Delivery System with Potential Applications

Krutisha Ajit Rane, Jameel Ahmed S Mulla

Abstract:
Targeted drug delivery is a critical strategy to enhance drug efficacy while minimizing side effects. Niosomes, a versatile drug carrier system, have gained prominence in this field. Niosomes, constructed from non-ionic surfactants and cholesterol, create minute lamellar formations, providing a mechanism for the encapsulation of both hygroscopic and oleopobic drugs. These structures exhibit numerous advantages, including biocompatibility, stability, and the ability to protect labile drugs. Hyaluronic acid (HA), a natural biopolymer, is valuable in drug delivery vehicles because of its biologically inert, decomposable, and site-specificity. HA is widely distributed in the body and has significant roles in various cellular processes, making it an attractive component for drug carriers. Furthermore, HA enhances drug permeation, with its effectiveness influenced by molecular weight. HA-coated niosomes have shown promise in various applications. In ocular drug delivery, they improve bioavailability by extending drug retention in the eye, overcoming the limitations of traditional eye drops. In the treatment of inflammation, these niosomes exhibit sustained anti-inflammatory effects, offering a potential solution for addressing inflammatory conditions. For anticancer drug delivery, CD44-targeted nanoparticles designed with HA enhance drug delivery efficiency to cancer cells, showing increased cytotoxicity and tumor growth inhibition. This review underscores the potential of HA-coated niosomes as a groundbreaking approach in advanced drug delivery. Their adaptability and ability to combine the strengths of niosomes and HA hold significant promise across diverse therapeutic domains, including ophthalmology, inflammation, and cancer treatment. This synergy represents a significant step toward personalized medicine and improved patient outcomes.

Keywords: Bilayer, Niosomes, Surfactants, Hyaluronic Acid, Transdermal Penetration.

A Promising Approach of Solid Dispersion for Enhancement of Solubility

Priyanka S Alekari, Vaishali A Patil, Sonal A Satpute

Abstract:
The preferred technique to increase the solubility of several medicines has been solid dispersion. Using the appropriate medium or polymer in conjunction with the solid dispersion of one or more active pharmaceutical ingredients in a carrier at a solid state is necessary to improve the dissolution of some low water-soluble medications and thus increase their bioavailability. It has attracted a lot of attention as a way to quicken up the disintegration rate. It occurs as a result of dispersing some water-soluble carriers with some weakly water-soluble medications to improve the pharmaceuticals’ disintegration. The solubility performance of pharmaceuticals is one of the most challenging areas of dosage form formulation and development. The amount of weakly water-soluble chemicals has significantly grown, prompting extra care to make them more soluble. The manufacture of solid dispersions must take into account a few factors, such as the choice of carrier and physicochemical characterization techniques. A brief overview of solid dispersion, including its characteristics, benefits, drawbacks, and uses in different formulations, is provided in this review article.

Keywords: Solubility, Dissolution, Solid Dispersion, Carrier, Bioavailability.

Overview on Transferosomes: A Unique Novel Nanocarrier System

Sonal A Satpute, Shraddha T Vaidya, Vaishali A Patil, Priyanka S Alekari

Abstract:
Today, transdermal delivery technologies are becoming more and more significant. Although transdermal drug administration has significantly improved medical practice, it still hasn’t reached its full potential as a substitute for oral medication delivery and hypodermic injections. A number of novel technologies have been developed to deliver some significant medications transdermally. The outermost layer of the skin, the lipophilic stratum corneum, is being studied by physical and chemical means. The majority of transdermal medicines that have proved effective do so by utilising smaller lipophilic compounds, which have molecular weights of a few hundred Daltons. Transferosomes have become an effective technique for transdermal distribution of a range of therapies, including hydrophilic actives, bigger molecules, peptides, proteins, and nucleic acids, in order to get around the medications’ size and lipophilicity constraints. A wide variety of pharmacological compounds, including big molecules like peptides, hormones, and antibiotics, as well as medications with low penetration owing to undesirable physicochemical characteristics, can be delivered via transfersomes with significant potential. Creating the medication in a transfersome is one way to address these issues. Because of its extreme deformability and elasticity, a transfersome can fit through a pore that is several times smaller than its actual size. The characteristics of transferosomes, their preparation process, and various assessment metrics are covered in this article.

Keywords: Transdermal, Transferosomes, Phospholipid, Edge Activator, Vesicular.

Enhancement in Flowability, Dissolution and Drug Release of Telmisartan through Spherical Crystallization

Rajkumar M Khade, Sachinkumar V Patil, Omkar B. Tipugade

Abstract:
A novel particle manufacturing process called spherical agglomeration can satisfy the requirements for direct compression. Telmisartan is an anti-hypertensive medicament which exhibits poor water solubility as well as flow properties. Spherical agglomerate was prepared by spherical crystallization technique. Dimethyl formamide and Dimethyl Sulfoxide performs as a good solvent, water as anti-solvent for Telmisartan and Dichloromethane, Chloroform and Ethyl Acetate act as binding liquid for agglomeration process. Prepared agglomerate was subjected for micromeritics as well as mechanical properties. Improvement in dissolution behaviour observed in formulation batches as compared to pure Telmisartan. The significant improvement in micromeritics properties observed because of size enlargement and spherical shape it revealed that the change in the crystal habit. A crucial step in creating a Telmisartan spherical agglomeration and a workable strategy for changing the material’s characteristics for direct compression is determining the processing parameters.

Keywords: Telmisartan, Spherical Crystallization Technique, Flowability, Compressibility.

Formulation and Evaluation of Herbal Lipstick of Beetroot Powder

Shivani N Mangulkar, Gajanan V Jadhav, Manaswi S Waghmare, Sakshi K Shivarkar, Shrushti S Masal, Rosalin M Alexander

Abstract:
In the recent times, lipsticks have been under the scanner of many health watchers’ lipsticks are often swallowed away by the users and hence it is imperative that health regulators have a microscopic look at the ingredients has go into the lipstick. The dyes that contribute to the color of the lipstick are dangerous to humans on consumption. Lipstick is generally accepted as an essential and leading make-up device available in variety of luster and texture. It is composed mainly of an oil-wax base, stiff enough to form a stick with a staining dye dissolved or dispersed in oil, and pigment suspended there in suitably performed and flavored, moulded and enclosed in a case. Lipstick imparts attractive color, glossy appearance to lips, accentuating good point and distinguishing the defects. It also prevents cracking of lips which lead to bacterial infection. It also provides emollient action on lips. Due to various adverse effects of available synthetic preparations, the present study was performed to formulate about F1 to F6 formulations and evaluate all the six formulations of herbal lipstick, as herbals are less prone to side effects, and due to usage of natural ingredients various adverse effects of the available synthetic preparations. The present study was performed without side effects and can be extensively used by the women with satisfaction.

Keywords: Herbal Lipsticks, Herbs, Formulation, Evaluation.

Formulation and Evaluation of Alcohol Based Polyherbal Hand Sanitizer

Nilam Metkari, Prajakta Sawant, Omkar Tipugade, Sipora Gaikwad

Abstract:
“Hand hygiene” is the primary goal in making a polyherbal hand sanitizer. It is an essential idea for the reduction, management, and prevention of any acquired infection. Generally speaking, hand sanitizers can break the chain of microbes and other bacteria that travel from our hands to other areas of our bodies. Maintaining good hand hygiene is crucial and one of the most important things to do when preparing food in homes, restaurants, and other day care facilities. Using hand sanitizer can prevent side effects such as dermatitis, itching, and irritation. Using five herbal extracts, distilled water, ethanol, methyl paraben, glycerol, and isopropyl alcohol, we made a polyherbal sanitizer. The compounds’ antibacterial qualities were taken into account prior to selection. It was discovered that the sanitizer’s pH ranged from 6.11 to 6.85. It was discovered that the sanitizer’s viscosity ranged from 380 to 800 cps. The range of 6.40 to 7.80 was determined to have high spreadability. For Mentha, the drug content in formulations was 88.6% in F1, 90.2 % in F2, and 92.8 % in F3. Similarly, for Tulsi, the drug content in formulations was 86.4% in F1, 93.1 % in F2, and 95.6% in F3. The results of the in-vitro drug release investigation showed that F1 was 65.9%, F2 was 70.5%, and F3 was 73.9%. The formulation F3 is the best, according to all of these investigations, because it has better drug content, pH, viscosity, spread ability, and in-vitro drug release trials.

Keywords: Herbal Extracts, Hand Hygiene, Anti-microbial Agents, Dispersion.

Combination of Natural and Cellulose Derivative Polymers to Control Sumatriptan Succinate Release from Unidirectional Buccal Patches

Sandhya Murali, Prasanth Vv, Sanjay K Bais

Abstract:
This study aimed to develop unidirectional mucoadhesive buccal patches of sumatriptan succinate (SUS) with the aid of natural polymers by solvent casting method. The SUS mucoadhesive buccal patches were fabricated using solvent casting combined with a 3² factorial design. Sodium alginate was used as a base polymer with Carbapol 934P, Chitosan, Hydroxy Propyl Methyl Cellulose and Poly Vinyl Pyrollidine K- 30. Polyethylene glycol and propylene glycol were employed as plasticizers. The final patches were cut into 2 cm diameters, backed with a water-resistant membrane, and covered in aluminum foil until further research. Sumatriptan succinate muco-adhesive buccal patches had good physicochemical characteristics. Mass uniformity varied from 41.36% to 84.18% and the thickness from 0.2 mm to 0.4 mm. The drug loading efficiency varied from 6.0 to 9.2 mg, with some formulations showing folding endurance over 300. Water-soluble characteristics of PVP K-30 and Carbapol 934P affected swelling index, residence time and drug release. In this study, formulation SC11 showed maximum drug release of 99.51% at 160 min and 99 % permeation rate at 140 min. Stability experiments showed that SC11’s drug content, residence time, and appearance are rarely affected. The prepared buccal patches of SUS appear to be potential formulations with respect to the physicochemical characteristics and in vitro evaluation data. These buccal patches may provide better bioavailability by avoiding the hepatic first-pass metabolism and provide more patient compliance.

Keywords: Transmucosal Drug Delivery, Unidirectional Buccal Patches, Mucoadhesion, Sumatriptan Succinate, Migraine, Sodium Alginate.

Indian Journal of

Novel Drug Delivery ISSN 0975-5500

Indian Journal of Novel Drug Delivery ISSN 0975-5500