Abstract:
Cubosomes that are unique nanovesicular systems those are important in drug administration. They are distinguished by their distinct bicontinuous cubic structures, which are created when amphiphilic lipids like phytantriol (PHYT) and glycerol monooleate (GMO) self-assemble. These nanocarriers, which usually have sizes between 100 and 500 nm, are good at delivering a range of drug types, including hydrophobic, hydrophilic, and and amphiphilic ones, because of their large surface area and encapsulating capacity. The word “cubosome” refers to its honeycomb-like cubic molecular structure, which facilitates efficient medication delivery and improved bioavailability. There are two main ways to manufacture cubosomes: the top-down method, which uses a high-energy dispersion of viscous cubic particles, and the bottom-up method, which uses liquid precursors to form spontaneously. Among the many benefits of cubosomes are their continuous drug release properties, biocompatibility, and capacity to shield delicate medications from deterioration. Because of their capacity to improve skin penetration and target certain biological barriers like the blood-brain barrier (BBB), they have demonstrated promise in a number of applications, including melanoma treatment, oral medication delivery, and cosmetic formulations. There are still issues, though, such as the difficulty of producing drugs on a big scale and the possibility of drug leakage during preparation and transportation. All things considered, cubosomes are a promising development in the realm of drug delivery systems, offering a unique combination of structural characteristics and adaptable uses that may greatly enhance therapeutic outcomes in a variety of medical fields.

Keywords: Cubosome, Top Down Method, Bottom Up Method, Drug Delivery.