Abstract: 
Breast cancer is still a major worldwide health concern, so new treatment approaches must be continuously investigated. Drug delivery methods based on nanoparticles have shown great promise in improving the effectiveness of anticancer medications by getting beyond biological obstacles such restricted penetration through tumour tissues. The purpose of this abstract is to give a brief summary of how well nanoparticle-based drug delivery systems work to improve the penetration of anticancer medications by using permeation enhancer, particularly those used to treat breast cancer.The field of epidemiological study has made substantial progress in our comprehension of the genetic and environmental factors that influence the risk of breast cancer. Breast cancer is the second most common cause of cancer-related fatalities in the United States, after lung cancer, and it is a major source of misery and early death among women worldwide. Epidemiological studies have established a number of risk factors for breast cancer, including race, ethnicity, family history of the disease, genetic predispositions, and modifiable exposures such as alcohol use, sedentary lifestyle, hormone use, and specific reproductive factors in women.This review examines the existing review on utilizing nanoparticle-based systems for delivering drugs in cancer treatment, and it evaluates their effectiveness. These nanoparticles hold promise in improving the delivery of anticancer drugs, decreasing toxicity in the body, and improving treatment outcomes. Numerous studies, both in preclinical and clinical settings, have demonstrated encouraging results. Nevertheless, there are hurdles like restricted drug loading, stability concerns, and potential adverse effects that must be overcome to facilitate their practical application in clinical settings.

Keywords: Breast cancer, Nanoparticle, Toxicity, Drug delivery Treatment.