Volume 16, Issue 4, Oct-Dec 2024

Volume 16

October-December 2024

Pulsatile Drug Delivery System (PDDS): An Overview

Arun J L

Abstract:
Pulsatile Drug Delivery systems (PDDS) are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, gastro-intestinal motility. System has to be developed to deliver drug according to circadian behavior of diseases. . A pulsatile drug release, where the drug is released rapidly after a well-defined lag-time, could be advantageous for many drugs or therapies. The potential benefits of chronotherapeutics have been investigated and established for number of diseases like asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcer, and hypercholesterolemia. This drug delivery system is programmed drug delivery system in harmonization with body clock. The pulse has to be designed in such a way that a complete and rapid dug release is achieved after the lag time. Various capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membranes are available in market. Therefore Pulsatile drug delivery is one such systems that, by delivering drug at the right time, right place and in right amounts, holds good promises of benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension. These systems are beneficial for diseases showing chronopharmacological behavior. These systems also improve patient compliance by decreasing dosing frequency.

Keywords: Time Controlling, Lag Time,Pulsatile Drug Release, Circadian Rhythm, Chronotherapeutics.

Polymeric Micelles for Targeted Drug Delivery: Recent Advances and Challenges

Leman P Gavit, Gangotri S Yadav, Ashish S Jain, Hrishikesh R More, Pratiksha V Pukale, Pratidnya S Patil

Abstract:
To improve drug delivery systems and to enhance the solubility and Minimizing side effects.to improve stability, and bioavailability of poorly water-soluble drugs. Polymeric micelles (PM) are revolutionising the field of medicine by improving the delivery of poorly soluble drugs, increasing their effectiveness, and lowering their side effects. This results in better gene therapies, targeted drug delivery, and more effective cancer treatments. To put it simply, PM make treatments more accurate and efficient, revolutionising patient care and personalised medicine. Polymeric micelles are paving the way for a future in which medications are safer, more effective. Polymeric micelles typically have a core-shell structure, with a hydrophobic core and a hydrophilic shell. This configuration allows them to encapsulate hydrophobic drugs within the core, enhancing their solubility and stability. Size: They usually range from 10 to 100 nm in size, which is ideal for drug delivery applications as it allows them to circulate in the bloodstream for extended periods and accumulate in target tissues through the enhanced permeability and retention (EPR) effect. Methods for development of micelles: Direct Dissolution, Precipitation/evaporation, Oil/water emulsion, Thin Film Hydration.

Keywords: Polymeric micelles, Colloid, Amphiphilic, Supramolecule, Nanocarriers.

Fast-Acting Oral Disintegrating Film for the Delivery of Teneligliptin Hydrobromide Hydrate

Shrishail M Ghurghure, Attar M Kais Sameer, Sumit S Umbardand

Abstract:
The current research work was aimed at optimizing and developing a fast-acting oral disintegrating film of teneligliptin hydrobromide hydrate so as to control the blood sugar level. Solvent casting was used to create the oral disintegrating film containing teneligliptin hydrobromide hydrate. Using a magnetic stirrer, the polymers necessary to prepare ODF were dissolved in an aqueous solution. Teneligliptin was dissolved in the polymer-containing aqueous solution mentioned above, and the mixture was then stirred with a magnetic stirrer. The previously mentioned polymeric solution was then combined with the remaining ingredients and stirred using a magnetic stirrer. Teneligliptin ODF formulations all showed outstanding folding endurance, suggesting that the formulation is robust enough to tolerate handling and transportation. The findings demonstrate the improved physical and chemical characteristics of the oral disintegrating film formulation, along with its good disintegration. The batch of teneligliptin hydrobromide hydrate ODF TF3 that has been optimized displays a pH of 5.8, an oral disintegration time of 45 S, and good folding endurance. The optimized batch’s medication content was discovered to be 96.3%. Every formulation batch has a moisture content that never varies more than 1.5%. This study’s findings show that teneligliptin’s ODF can be created with the intention of improving therapeutic efficacy, increasing bioavailability, and improving patient compliance. Evaluations of the films’ thickness, weight homogeneity, drug content, folding durability, in-vitro release, and disintegration time revealed that they were satisfactory.

Keywords: Disintegrating property, Insulin secretion, Oral disintegrating film, Teneligliptin hydrobromide hydrate.

Design, Development and Evaluation of Anthelmintic Candy for Paediatric Use

Sanjana S, Sneha H C

Abstract:
There was a need for innovative dosage forms that would both minimize first pass metabolism and boost bioavailability despite the wide variety of dosage forms already on the market. The goal of the enhanced research effort was to decrease first pass metabolism and increase bioavailability. Due to its simplicity of swallowing, ability to prevent pain, and most importantly patient compliance, the oral route of medication administration was a very popular form of drug administration. Candy was designed to dissolve gradually in the tongue and was a solid dose form that contained medication in a foundation that was sweetened and flavoured. Candies are pharmaceutical dose forms that are meant to be given to children. They contain albendazole in order for the candy to melt readily in the child’s mouth. After boiling sugar and water to make candy, the medication albendazole was added and thoroughly blended. The prepared liquid was poured into the calibrated mold, and it was left outside to dry for a few hours. The made candy was stored in desiccators, wrapped in aluminium foil to keep moisture out.

Keywords: Albendazole, Medicated candy, Anthilmintic.

Formulation and Evaluation of Clove and Eucalyptus Extracts Loaded Dental Film for Treatment of Periodontal Disease

Mohammadkaif Javed Nadaf, Jameel Ahmed S Mulla

Abstract:
The study focuses on the formulation and evaluation of a novel dental film incorporating clove (Syzygium aromaticum) and eucalyptus (Eucalyptus globulus) extracts, aimed at providing an effective localized therapy for periodontal disease. Periodontal disease, characterized by inflammation and degeneration of the supporting structures of the teeth, remains a significant public health concern, necessitating the development of innovative, targeted treatment modalities. In this research, herbal extracts known for their potent antimicrobial, anti-inflammatory, and analgesic properties were incorporated into a biodegradable film matrix, designed to adhere to periodontal pockets and deliver sustained therapeutic effects. The dental films were prepared using a solvent casting method, with optimal concentrations of clove and eucalyptus extracts and different concentrations and ratios of polymers. The physicochemical properties, including thickness, weight variation, surface pH, percentage moisture loss, percentage moisture absorption and folding endurance, were systematically evaluated. In vitro studies assessed the release profile of active compounds, while antimicrobial efficacy was determined against common periodontal pathogens using disk diffusion method. The results demonstrated that the formulated dental films exhibited desirable mechanical properties, controlled drug release, and significant antimicrobial activity against Staphylococcus aureus. These findings suggest that clove and eucalyptus extract-loaded dental films could serve as an effective, patient-friendly adjunct in the management of periodontal disease, offering localized, sustained therapeutic benefits with minimal side effects.

Keywords: Clove extract, Eucalyptus extract, Polyherbs, Dental film, Periodontal disease, Antibacterial activity.

Indian Journal of

Novel Drug Delivery ISSN 0975-5500